Mission
We are devoted to study immune-evasion mechanisms, especially the ones favoring the development of tumors. Our main technological approach combines multiphoton intravital microscopy to functional reporters of biological processes (functional intravital microscopy or F-IVM). Our long-term goal is to devise new forms of immunotherapy through the manipulation of immune-evasion mechanisms.
Impact of checkpoint blockade on tumor-associated T regulatory cells
Checkpoint blockade immunotherapy has provided durable benefits for many patients with metastatic disease, yet many more still do not respond to the treatment. Â In this line of research we investigate whether checkpoint blockade immunotherapy enhances the function of tumor-associated Treg, which in turn may limit therapeutic efficacy.
Reprogramming of tumor-associated macrophages
Tumor-associated macrophages (TAM) can oppose or promote tumor growth depending on their propensity to support or dampen inflammation, respectively. Â This project hinges on new mouse models allowing to map the function of TAM to identify the factors leading to TAM reprogramming towards pro-inflammatory functions in vivo.
